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Section 7.1 Laboratory

Laboratory Report #25

Date

Collection Date: July 26, 2022
Report Date: August 4, 2022

Laboratory

Quest Diagnostics

Performing Laboratory:
Mayo Clinic Laboratories
Rochester, Minnesota

Ordering Physician

Dr. Maryam Saifi

Report Type

Specialized Allergy / Mast Cell Evaluation

Laboratory testing included:

  • 24-Hour Urine 2,3-Dinor-11β-Prostaglandin F2α (2,3-BPG)
  • 24-Hour Urine Creatinine
  • Urine Volume
  • Collection Duration

Original Report

PDF: Quest Diagnostics – July 26, 2022 (24-Hour Urine 2,3-Dinor-11β-Prostaglandin F2α)

One-Page Summary

Purpose of Testing

This specialized laboratory evaluation was performed as part of the diagnostic investigation for mast cell activation disorders (MCAD/MCAS). The test measures 2,3-Dinor-11β-Prostaglandin F2α, a urinary metabolite of prostaglandin D₂ released by activated mast cells. It complements serum tryptase and urinary N-methylhistamine testing by evaluating another biochemical pathway associated with mast cell activation.

Major Findings

24-Hour Urine 2,3-Dinor-11β-Prostaglandin F2α

Result

  • <513 pg/mg Creatinine

Reference Range:

  • <1802 pg/mg Creatinine

Interpretation

The urinary 2,3-Dinor-11β-Prostaglandin F2α level was well within the normal reference range.

This finding indicates:

  • No laboratory evidence of increased prostaglandin production from mast cells.
  • No biochemical evidence of ongoing mast cell activation.
  • Additional evidence against mast cell activation syndrome (MCAS) or systemic mastocytosis.

Because this result is substantially below the upper reference limit, it provides reassuring evidence that prostaglandin-mediated mast cell activity was not increased at the time of testing.

Collection Quality

Twenty-Four-Hour Urine Collection

Collection Duration

  • 24 hours

Urine Volume

  • 2,200 mL

24-Hour Creatinine

  • 1,342 mg/24 hr

Reference Range:

  • 930–2,955 mg/24 hr

Creatinine Concentration

  • 61 mg/dL

Interpretation

The urine collection appears complete and adequate for interpretation. Normal creatinine excretion supports the validity of the test results and increases confidence in the normal prostaglandin measurement.

Clinical Significance

This report addressed another important diagnostic question:

“Could excessive prostaglandin release from mast cells explain the inflammatory illness?”

The answer provided by this laboratory study is no evidence to support that diagnosis.

The laboratory also notes an important testing consideration:

  • Aspirin taken within two weeks or other NSAIDs taken within 72 hours before testing may lower this marker and should be considered when interpreting results.

Overall Interpretation

This specialized Mayo Clinic laboratory evaluation demonstrated a normal 24-hour urinary 2,3-Dinor-11β-Prostaglandin F2α level. The result provides additional evidence against mast cell activation disorders as the cause of your previous inflammatory illness. When interpreted together with the normal serum tryptase and normal urinary N-methylhistamine studies, the laboratory findings consistently argue against abnormal mast cell activation.

Longitudinal Significance

This report contributes to:

  • Mast Cell Disorder Evaluation
  • Allergy / Immunology Evaluation
  • Differential Diagnosis Archive
  • Rheumatology Consultation Summary
  • Systemic Inflammatory Illness Timeline
  • Medical History Timeline

It represents the third specialized laboratory study evaluating mast cell biology.

Clinical Importance

⭐⭐⭐ Diagnostic Exclusion Study

Although this report contains only one specialized biomarker, it is valuable because it completes another major portion of the diagnostic evaluation performed after your inflammatory illness.

Key Findings

  • 2,3-Dinor-11β-Prostaglandin F2α: <513 pg/mg Creatinine (Normal)
  • 24-Hour Creatinine: 1,342 mg/24 hr (Normal)
  • Collection Duration: 24 hours
  • Urine Volume: 2,200 mL
  • Overall Interpretation: No laboratory evidence of excessive prostaglandin production from mast cell activation.

Related Reports

  • July 26, 2022 – Serum Tryptase Evaluation
  • July 26, 2022 – 24-Hour Urine N-Methylhistamine Evaluation
  • Autoimmune Evaluation
  • Allergy / Immunology Evaluation
  • Rheumatology Consultation Summary
  • Systemic Inflammatory Illness Timeline
  • Medical History Timeline

Navigation

  • Previous Report: July 26, 2022 – 24-Hour Urine N-Methylhistamine Evaluation
  • Next Report: Subsequent Laboratory Evaluation
  • Return to Laboratory Library
  • Return to Health Inventory

Observation

These three specialized studies from July 2022 form an excellent diagnostic series and should be linked together in your Health Inventory:

  1. Serum Tryptase – Normal
  2. 24-Hour Urine N-Methylhistamine – Normal
  3. 24-Hour Urine 2,3-Dinor-11β-Prostaglandin F2α – Normal

Taken together, they evaluate three different biochemical pathways of mast cell activity. The fact that all three were normal provides strong evidence that mast cell activation was not the source of your prior systemic inflammatory illness. This three-test series is one of the strongest examples in your Health Inventory of how physicians systematically ruled out potential causes before concluding that the illness represented a severe but ultimately resolving inflammatory syndrome.